Polycythemia associated with the JAK2V617F mutation emerged during treatment of chronic myelogenous leukemia
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چکیده
منابع مشابه
Strategic treatment interruptions during imatinib treatment of chronic myelogenous leukemia.
Although imatinib is an effective treatment for chronic myelogenous leukemia (CML), and nearly all patients treated with imatinib attain some form of remission, imatinib does not completely eliminate leukemia. Moreover, if the imatinib treatment is stopped, most patients eventually relapse (Cortes et al. in Clin. Cancer Res. 11:3425-3432, 2005). In Kim et al. (PLoS Comput. Biol. 4(6):e1000095, ...
متن کاملTwo Cases of Myeloproliferative Neoplasm with a Concurrent JAK2V617F Mutation and BCR/ABL Translocation without Chronic Myelogenous Leukemia Phenotype Acquisition during Hydroxyurea Treatment
Sang Hyuk Park, M.D., Hyun-Sook Chi, M.D., Young-Uk Cho, M.D., Seongsoo Jang, M.D., Chan-Jeoung Park, M.D., Dae-Young Kim, M.D., Je-Hwan Lee, M.D., and Kyoo-Hyung Lee, M.D. Department of Laboratory Medicine, University of Ulsan, College of Medicine and Asan Medical Center; Department of Internal Medicine, Division of Hematology, University of Ulsan, College of Medicine and Asan Medical Center, ...
متن کاملJAK2V617F mutation in chronic myeloid leukemia predicts early disease progression.
OBJECTIVE To determine the association of JAK2V617F mutation along with BCR-ABL translocation or Philadelphia chromosome in chronic myeloid leukemia with early disease progression to advanced stages (accelerated phase or blast crisis) and poor outcome. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, from Fe...
متن کاملTreatment of the individual patient with chronic myelogenous leukemia.
young lady has a routine blood examination which shows a WBC of 15x10 9 /L with absolute neutrophilia and a few metamyelo-cytes and myelocytes. She was fine before this check, but her life now changes dramatically. In fact, when patients with chronic-phase CML are fully informed about the natural history of their disease , they view the blast crisis as a sort of sword of Damocles hanging over t...
متن کاملFunction of Neutrophils in Different Phases of Chronic Myelogenous Leukemia
In chronic myelogenous leukemia (CML), the mature granulocytes originate from a stem cell line harboring an abnormal chromosome, therefore it is possible that metabolic-functional abnormalities occur in the morphologically mature cells. In the present study, the phagocytic activity including intracellular killing, nitro blue tetrazolium (NBT) reduction, and phagocytosis were studied in 37 CML p...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2007
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2404591